MAF 878, as used by Dr. Enlander, has brought slow benefit to a majority of the 40 patients who take it. Some of these patients take MAF 878 by itself; others take it in combination with injected GcMAF. As is his usual fashion, Dr. Enlander tracks his patients on this treatment. Preliminary results indicate that MAF 878 elevates NK cell function (LU30 test). Dr. Enlander has observed that MAF 878 seems to work especially well for IBS patients.
At the moment it is not clear how long these compounds need to be taken, if they need to be stopped when Nagalase is lowered into the normal range, whether there is a maintenance dose, or whether Nagalase, once lowered, stays lowered or how fast it rises again, if it does so. So we are in unknown territory with much of this therapy. A few clinicians are sharing information as it accumulates but, as with all ME/CFS treatments, not much is known and nothing reaches the level of real scientific data. Such is the world of ME/CFS. If an effective treatment ever does arrive for ME/CFS, most patients will never learn about it, and it will not reach the level of being scientifically supported.
My own observational experience is that probiotic MAF “does something”. I know a number of patients who take one version or another of the probiotic MAF. All who take it experience a slow and general “strengthening”. Some report improved sleep.