Monday, January 28, 2013

Anatabloc


The preliminary results of a Hashimoto’s thyroiditis trial involving Anatabloc was released a few days ago. The complete study will be released soon. The results were intriguing - to say the least.

148 subjects with proven Hashimoto's thyroiditis were given an anatabine-based substance, Anatabloc. The study occurred in a “three-month, five-visit, double-blind, placebo controlled” environment of nine sites.

The preliminary results release is here

The key point is:

"The preliminary examination of the primary outcomes shows a clear and statistically significant difference in the treated group as compared to the placebo group by the end of the trial, with declines in anti-thyroglobulin antibody levels.  Anatabine subjects also tended toward a reduction in thyroid gland vascularity on ultrasound relative to placebo.”

(Why they didn’t measure TPO is a modern wonder.)

Dr. Paul Landenson, a noted endocrinologist, says this:
“Data from this rigorously conducted, placebo-controlled, double blind trial show that anatabine-treated subjects had progressive decreases in circulating thyroglobulin antibody levels, which became significant by the end of the trial. Current treatment for autoimmune thyroiditis is limited to end-stage disease when irreversible gland damage necessitates lifelong thyroid hormone replacement. The prospect of a novel nutritional or pharmaceutical intervention that could preserve thyroid health represents an encouraging advance. Further clinical studies are now warranted.”

It appears that Anatabloc is a powerful NF Kappa B inhibitor. Dr. Paul Cheney and others talk of the importance of inhibiting NK Kappa B in ME/CFS.

If this data holds up, it will be the first treatment to reduce an autoimmune disease in humans. 

There is ample anecdotal evidence that Anatabloc works on more than thyroiditis.

Anatabine is an alkaloid compound. It is found in eggplants, tomatoes (especially green tomatoes), and bell peppers. This compound might help explain part of the anti-inflammatory benefits derived from vegetable juicing.

It will be interesting if someone does a trial with Anatabloc in ME/CFS patients - to see if it might lower il-8, c4a, MMP-9, CRPs or tumor necrosis factor.

Here is an article on STTM, with some comments.

Further pro-Anatabloc commentary can be found here and here. There are other anecdotal comments on forums. I assume that interested readers can make their own way through this with an equal measure of excitation and disbelief. 

Anatabloc has a Facebook page here.

2 comments:

  1. check this out

    http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0055392

    chris

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  2. Is there any information about anatabine and a healthy thyroid. I was taking anatabine as well as metformin and my latest TSH is very low.

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